Synthesis of New Bis-pyrazolines Endowed with Potent Antifungal Activity against Candida albicans and Aspergillus niger

SEVER B., ALTINTOP M. D., ÖZDEMİR A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.18, no.1, pp.3-15, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.2174/1570180817999201008155247
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Page Numbers: pp.3-15
  • Keywords: Bis-pyrazoline, dithiocarbamate, oxadiazole, antifungal activity, aspergillosis and candidiasis, BIOLOGICAL EVALUATION, DERIVATIVES BEARING, DRUG-RESISTANCE, GROWTH, DISCOVERY, VIRULENCE, MOIETY
  • Anadolu University Affiliated: Yes

Abstract

Background: Due to the increasing number of cases of invasive fungal infections (IFIs), there is an urgent need to identify potent antifungal agents capable of combating IFIs. Pyrazolines are one such class of therapeutically active agents that could be considered to fulfill this need.