LIFE SCIENCES, vol.261, 2020 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
AMPA antagonist, Anxiety, GABA, Norepinephrine, Perampanel, Serotonin, AMPA-RECEPTOR ANTAGONIST, ELEVATED PLUS-MAZE, HOLE-BOARD TEST, ANIMAL-MODELS, LOCOMOTOR-ACTIVITY, RAT-BRAIN, ANXIETY, RELEASE, BEHAVIOR, NOREPINEPHRINE
Anadolu University Affiliated:
Aims: The aim of this study is to investigate the anxiolytic activity of perampanel, a non-competitive antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors, which is approved for partial-onset seizures in patients with epilepsy, and its mechanism of action.