Copy For Citation
BEKTAŞ TÜRKMEN N., ARSLAN R., ALYU ALTINOK F.
LIFE SCIENCES, vol.261, 2020 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
261
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Publication Date:
2020
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Doi Number:
10.1016/j.lfs.2020.118359
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Journal Name:
LIFE SCIENCES
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
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Keywords:
AMPA antagonist, Anxiety, GABA, Norepinephrine, Perampanel, Serotonin, AMPA-RECEPTOR ANTAGONIST, ELEVATED PLUS-MAZE, HOLE-BOARD TEST, ANIMAL-MODELS, LOCOMOTOR-ACTIVITY, RAT-BRAIN, ANXIETY, RELEASE, BEHAVIOR, NOREPINEPHRINE
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Anadolu University Affiliated:
Yes
Abstract
Aims: The aim of this study is to investigate the anxiolytic activity of perampanel, a non-competitive antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors, which is approved for partial-onset seizures in patients with epilepsy, and its mechanism of action.