The anxiolytic effect of perampanel and possible mechanisms mediating its anxiolytic effect in mice

BEKTAŞ TÜRKMEN N., ARSLAN R., ALYU ALTINOK F.

LIFE SCIENCES, vol.261, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 261
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.118359
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: AMPA antagonist, Anxiety, GABA, Norepinephrine, Perampanel, Serotonin, AMPA-RECEPTOR ANTAGONIST, ELEVATED PLUS-MAZE, HOLE-BOARD TEST, ANIMAL-MODELS, LOCOMOTOR-ACTIVITY, RAT-BRAIN, ANXIETY, RELEASE, BEHAVIOR, NOREPINEPHRINE
  • Anadolu University Affiliated: Yes

Abstract

Aims: The aim of this study is to investigate the anxiolytic activity of perampanel, a non-competitive antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors, which is approved for partial-onset seizures in patients with epilepsy, and its mechanism of action.