Effects of Hypericum calycinum L extract on the central nervous system in mice

ÖZTÜRK Y., Aydin S., Beis R., Baser K., Berberoglu H.

PHYTOTHERAPY RESEARCH, vol.10, no.8, pp.700-702, 1996 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 8
  • Publication Date: 1996
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.700-702
  • Keywords: Hypericum calycinum, antidepressant drugs, depression, analgesia, central nervous system, FORCED SWIMMING TEST, PERFORMANCE, RATS
  • Anadolu University Affiliated: Yes


Hypericum species have been used as herbal remedies for the therapy of various neurological disorders. In the present study, the effects of Hypericum calycinum on the central nervous system were investigated using various behavioural models including swimming time, locomotor activity, tail-flick and hole-board experiments. According to the results obtained, it was found that the extract prepared from H. calycinum is as effective as the antidepressant drugs, desipramine and trimipramine, which were used for comparison with this plant extract in animal models.