Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells

DEMİROĞLU ZERGEROĞLU A., ERGENE E., Ayvali N., Kuete V., SİVAS H.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, cilt.16, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1186/s12906-016-1267-x
  • Dergi Adı: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Cell cycle, Cisplatin, JNK, MAPK, Mesothelioma, Quercetin, p38, APOPTOSIS, P38, INHIBITION, PATHWAYS, JNK, ERK, P53, PHOSPHORYLATION, PREVENTION, COMPLEX
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination with Cisplatin inhibits cell proliferation and activates caspase-9 and -3 enzymes in different malignant mesothelioma cell lines. Moreover, Quercetin + Cisplatin lead to accumulation of both SPC111 and SPC212 cell lines in S phase.