Quercetin and Cisplatin combined treatment altered cell cycle and mitogen activated protein kinase expressions in malignant mesotelioma cells

DEMİROĞLU ZERGEROĞLU A., ERGENE E., Ayvali N., Kuete V., SİVAS H.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol.16, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2016
  • Doi Number: 10.1186/s12906-016-1267-x
  • Journal Name: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Cell cycle, Cisplatin, JNK, MAPK, Mesothelioma, Quercetin, p38, APOPTOSIS, P38, INHIBITION, PATHWAYS, JNK, ERK, P53, PHOSPHORYLATION, PREVENTION, COMPLEX
  • Anadolu University Affiliated: Yes

Abstract

Background: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination with Cisplatin inhibits cell proliferation and activates caspase-9 and -3 enzymes in different malignant mesothelioma cell lines. Moreover, Quercetin + Cisplatin lead to accumulation of both SPC111 and SPC212 cell lines in S phase.