Atıf İçin Kopyala
DEMİROĞLU ZERGEROĞLU A., ERGENE E., Ayvali N., Kuete V., SİVAS H.
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, cilt.16, 2016 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
16
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Basım Tarihi:
2016
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Doi Numarası:
10.1186/s12906-016-1267-x
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Dergi Adı:
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Anahtar Kelimeler:
Cell cycle, Cisplatin, JNK, MAPK, Mesothelioma, Quercetin, p38, APOPTOSIS, P38, INHIBITION, PATHWAYS, JNK, ERK, P53, PHOSPHORYLATION, PREVENTION, COMPLEX
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Anadolu Üniversitesi Adresli:
Evet
Özet
Background: Malignant mesothelioma is a locally aggressive and highly lethal neoplasm of pleural, peritoneal and pericardial mesothelial cells without successful therapy. Previously, we reported that Quercetin in combination with Cisplatin inhibits cell proliferation and activates caspase-9 and -3 enzymes in different malignant mesothelioma cell lines. Moreover, Quercetin + Cisplatin lead to accumulation of both SPC111 and SPC212 cell lines in S phase.