Synthesis and Antimicrobial Activity of Some Novel Benzimidazole Hydrazides

Ozkay Y., Tunali Y., Karaca H., Isikdag I.

ASIAN JOURNAL OF CHEMISTRY, vol.23, no.4, pp.1503-1508, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 4
  • Publication Date: 2011
  • Journal Name: ASIAN JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1503-1508
  • Keywords: Benzimidazole, Hydrazide, Antimicrobial, Brine-Shrimp lethality assay, ANTIFUNGAL ACTIVITY, POTENTIAL ANTIBACTERIAL, ACID HYDRAZIDE, DERIVATIVES, HYDRAZONES, ANALOGS, QSAR, IMIDAZOLE
  • Anadolu University Affiliated: Yes

Abstract

The present study was undertaken to synthesize some 4-(5,6-dichloro-1H-benzimidazole-2-yl)phenoxyacetic acid-4-substituted benzylidene hydrazide derivatives and investigate their possible antimicrobial activity. Chemical structures of the synthesized compounds were elucidated by IR, H-1 NMR and ES-MS spectral data and elemental analysis. Some of the compounds in the series exhibited notable antibacterial activity against various bacterial strains. Besides, most of them displayed significant antifungal activity against different Candida yeasts. Microbiological studies revealed that the most active compounds in the series were 6d and 6n, which were also evaluated in Brine-Shrimp lethality assay. The compound 6d was found as non-toxic in addition to its significant antimicrobial activity, whereas the compound 6n was determined as harmful.