Anticancer Activity of Some Bisbenzimidazoles
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, sa.9-10, ss.465-470, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2011
- Doi Numarası: 10.1515/znc-2011-9-1005
- Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.465-470
- Anahtar Kelimeler: Bisbenzimidazole, Anticancer, DNA Topoisomerase, DNA, TOPOISOMERASES, CYTOTOXICITY
- Anadolu Üniversitesi Adresli: Evet
Özet
The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some symmetrical bisbenzimidazole derivatives were synthesized and investigated for their anticancer activity. Anticancer activity screening was applied on HT-29 (colon carcinoma) and MCF-7 (breast carcinoma) cell lines by investigation of cytotoxicity, analysis of DNA synthesis, and DNA fragmentation assays. One of the seven compounds tested showed significant cytotoxicity in both cell lines and caused DNA degradation in the HT-29 cell line.