SOME 3-ALKYL-6-(2-ARYL-2-OXO-1-ETHYL)-7-OXOTHIAZOLO[4,5-d]PYRIMIDIN-2(3H)-THIONE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITIES

Demirayak S., Kayagil I., Tunali Y.

ISTANBUL JOURNAL OF PHARMACY, vol.38, no.1, pp.79-85, 2005 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2005
  • Journal Name: ISTANBUL JOURNAL OF PHARMACY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.79-85
  • Keywords: 7-Oxothiazolo[4,5-d]pyrimidin-2(3H)-thione, thiazole, antimicrobial activity
  • Anadolu University Affiliated: Yes

Abstract

In this study, some 3 -alkyl-6-(2-aryl-2-oxo-1-ethyl)-7-oxothiazolo[4,5-d]pyrirnidin-2(3H)-thione derivatives have been synthesized by reacting 3-alkyl-7-oxothiazolo [4,5-d]pyrimidin-2(3H)-thiones with various co-bromoacetophenones. The antibacterial and antifungal activities of the obtained compounds have been investigated and it is reported that some of the compounds showed remarkable antimicrobial activities.