EFFECTS OF THE AGENTS AFFECTING CYCLIC-NUCLEOTIDE METABOLISM ON THE BRADYKININ-INDUCED AND DES-ARG(9)-BRADYKININ-INDUCED RELAXATIONS AND CONTRACTIONS IN ISOLATED RAT DUODENUM

ÖZTÜRK Y.

GENERAL PHARMACOLOGY, cilt.25, sa.7, ss.1389-1395, 1994 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 7
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0306-3623(94)90163-5
  • Dergi Adı: GENERAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1389-1395
  • Anahtar Kelimeler: BRADYKININ, CYCLIC AMP, CYCLIC GMP, RAT DUODENUM, KININ RECEPTORS, SMOOTH-MUSCLE RELAXATION, RECEPTOR ANTAGONISTS, KININ RECEPTORS, METHYLENE-BLUE, GMP, NITROGLYCERIN, ACTIVATION, SITES
  • Anadolu Üniversitesi Adresli: Evet

Özet

1. Bradykinin and related kinins possess two different types of action (consisting of relaxation and contraction) in the isolated rat duodenum via their specific receptors. However, the mechanisms of these actions have not been fully elucidated. The present study was undertaken to investigate the effects of the agents affecting cyclic nucleotide metabolism on bradykinin-induced relaxations and on bradykinin- and des-Arg(9)-bradykinin-induced contractions.