GENERAL PHARMACOLOGY, vol.25, no.7, pp.1389-1395, 1994 (SCI-Expanded)
1. Bradykinin and related kinins possess two different types of action (consisting of relaxation and contraction) in the isolated rat duodenum via their specific receptors. However, the mechanisms of these actions have not been fully elucidated. The present study was undertaken to investigate the effects of the agents affecting cyclic nucleotide metabolism on bradykinin-induced relaxations and on bradykinin- and des-Arg(9)-bradykinin-induced contractions.