EFFECTS OF THE AGENTS AFFECTING CYCLIC-NUCLEOTIDE METABOLISM ON THE BRADYKININ-INDUCED AND DES-ARG(9)-BRADYKININ-INDUCED RELAXATIONS AND CONTRACTIONS IN ISOLATED RAT DUODENUM

ÖZTÜRK Y.

GENERAL PHARMACOLOGY, vol.25, no.7, pp.1389-1395, 1994 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 7
  • Publication Date: 1994
  • Doi Number: 10.1016/0306-3623(94)90163-5
  • Journal Name: GENERAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1389-1395
  • Keywords: BRADYKININ, CYCLIC AMP, CYCLIC GMP, RAT DUODENUM, KININ RECEPTORS, SMOOTH-MUSCLE RELAXATION, RECEPTOR ANTAGONISTS, KININ RECEPTORS, METHYLENE-BLUE, GMP, NITROGLYCERIN, ACTIVATION, SITES
  • Anadolu University Affiliated: Yes

Abstract

1. Bradykinin and related kinins possess two different types of action (consisting of relaxation and contraction) in the isolated rat duodenum via their specific receptors. However, the mechanisms of these actions have not been fully elucidated. The present study was undertaken to investigate the effects of the agents affecting cyclic nucleotide metabolism on bradykinin-induced relaxations and on bradykinin- and des-Arg(9)-bradykinin-induced contractions.