EFFICACY OF PROPHYLACTIC AND EARLY FLUCONAZOLE TREATMENT ON SYSTEMIC CANDIDIASIS IN EXPERIMENTALLY NEUTROPENIC RABBITS

OZGUNES I., USLUER G., GURER F., COLAK H.

CHEMOTHERAPY, vol.39, no.3, pp.189-196, 1993 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 3
  • Publication Date: 1993
  • Doi Number: 10.1159/000239125
  • Journal Name: CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.189-196
  • Keywords: SYSTEMIC CANDIDIASIS, FLUCONAZOLE, NEUTROPENIA, HEPATIC CANDIDIASIS, CANCER-PATIENTS, MODEL
  • Anadolu University Affiliated: No

Abstract

The efficacy of prophylactic and early fluconazole treatment on experimental systemic candidiasis was investigated in neutropenic rabbits. Fifteen rabbits were used and divided into three groups: fluconazole was started 24 h before the inoculation of Candida albicans in the first group, and 24 h after the inoculation in the second group. The third group was the control group without antifungal therapy. Prophylactic and early fluconazole treatment for 7 days after C. albicans inoculation did not reduce the mortality and tissue culture positivity in the rabbits significantly. Four of the five rabbits survived 7 days both in the prophylactic and early treatment groups. However, only one rabbit survived for 7 days in the control group. In diagnostic procedures, histopathological examination and evaluation with periodic acid-Schiff stain was found to be the most sensitive. In this study, prophylactic and early fluconazole treatment were found to be insufficent for treatment of systemic candidiasis in neutropenic rabbits.