EFFICACY OF PROPHYLACTIC AND EARLY FLUCONAZOLE TREATMENT ON SYSTEMIC CANDIDIASIS IN EXPERIMENTALLY NEUTROPENIC RABBITS

OZGUNES I., USLUER G., GURER F., COLAK H.

CHEMOTHERAPY, cilt.39, sa.3, ss.189-196, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1159/000239125
  • Dergi Adı: CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.189-196
  • Anahtar Kelimeler: SYSTEMIC CANDIDIASIS, FLUCONAZOLE, NEUTROPENIA, HEPATIC CANDIDIASIS, CANCER-PATIENTS, MODEL
  • Anadolu Üniversitesi Adresli: Hayır

Özet

The efficacy of prophylactic and early fluconazole treatment on experimental systemic candidiasis was investigated in neutropenic rabbits. Fifteen rabbits were used and divided into three groups: fluconazole was started 24 h before the inoculation of Candida albicans in the first group, and 24 h after the inoculation in the second group. The third group was the control group without antifungal therapy. Prophylactic and early fluconazole treatment for 7 days after C. albicans inoculation did not reduce the mortality and tissue culture positivity in the rabbits significantly. Four of the five rabbits survived 7 days both in the prophylactic and early treatment groups. However, only one rabbit survived for 7 days in the control group. In diagnostic procedures, histopathological examination and evaluation with periodic acid-Schiff stain was found to be the most sensitive. In this study, prophylactic and early fluconazole treatment were found to be insufficent for treatment of systemic candidiasis in neutropenic rabbits.