Evaluation of carvedilol-loaded Eudragit (R) nanoparticles

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Güven U. M., Öztürk A. A., Yenilmez E.

JOURNAL OF RESEARCH IN PHARMACY, cilt.24, sa.1, ss.71-81, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.35333/jrp.2020.116
  • Dergi Adı: JOURNAL OF RESEARCH IN PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.71-81
  • Anahtar Kelimeler: Nanoparticles, drug delivery, controlled release system, carvedilol, spray dry, IN-VITRO CHARACTERIZATION, POLYMERIC NANOPARTICLES, OLOPATADINE HYDROCHLORIDE, ORAL BIOAVAILABILITY, PLGA NANOPARTICLES, VIVO EVALUATION, KOLLIDON(R) SR, RS 100, FORMULATION, DELIVERY
  • Anadolu Üniversitesi Adresli: Evet

Özet

The objective of present study was to prepare positively charged carvedilol-loaded nanoparticles providing a controlled release formulation by spray dryer technique and was to examine the effect of different derivative of Eudragit (R) polymers on entrapment efficiency (EE%), dissolution profile and release kinetics. Two non-biodegradable positively charged polymers, Eudragit (R) RS100 and RL100 were used alone or in combination. The prepared formulations were evaluated for their particle size, polydispersity index, zeta potential, in vitro dissolution and in vitro release kinetics study. Particle sizes of placebo nanoparticles and carvedilol loaded nanoparticles were 418.2 +/- 18.5/ 402.3 +/- 22.0/ 416.3 +/- 12.5 and 535.5 +/- 13.8/ 529.4 +/- 10.2/ 530.4 +/- 10.4 nm, respectively with PDI values of approximately 0.4-0.6 for each. Carvedilol loading was resulted in positive electrical charge on nanoparticles. The drug encapsulation efficiency was 68.45 +/- 4.67/ 63.58 +/- 2.30/ 65.67 +/- 4.21. In vitro cumulative release from the nanoparticles was 80-90 % at 48 hour. Morphology and solid state analyzes were performed also in nanoparticles. The results of this research indicate that spray dryer technique is suitable for carvedilol loaded Eudragit (R) nanoparticles and no burst effect but a prolonged drug release was observed from formulations.