Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs
PHARMACOLOGICAL RESEARCH, cilt.49, sa.3, ss.287-292, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 3
- Basım Tarihi: 2004
- Doi Numarası: 10.1016/j.phrs.2003.10.007
- Dergi Adı: PHARMACOLOGICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.287-292
- Anahtar Kelimeler: propolis, tuberculosis, prevention, guinea-pig, water extract, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, ANTIBACTERIAL ACTIVITY, CHEMICAL-COMPOSITION, BRAZILIAN PROPOLIS, ACTIVATION, ANTITUMOR
- Anadolu Üniversitesi Adresli: Evet
Özet
Mycobacterium tuberculosis (H37Rv)-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n = 9), isoniazid (n = 5) or saline (n = 6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P > 0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P > 0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model. (C) 2003 Elsevier Ltd. All rights reserved.