Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs

Yildirim Z., HACIEVLİYAGİL S. S., Kutlu N., Aydin N., Kurkcuoglu M., Iraz M., ...More

PHARMACOLOGICAL RESEARCH, vol.49, no.3, pp.287-292, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2004
  • Doi Number: 10.1016/j.phrs.2003.10.007
  • Journal Name: PHARMACOLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.287-292
  • Keywords: propolis, tuberculosis, prevention, guinea-pig, water extract, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, ANTIBACTERIAL ACTIVITY, CHEMICAL-COMPOSITION, BRAZILIAN PROPOLIS, ACTIVATION, ANTITUMOR
  • Anadolu University Affiliated: No

Abstract

Mycobacterium tuberculosis (H37Rv)-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n = 9), isoniazid (n = 5) or saline (n = 6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P > 0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P > 0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model. (C) 2003 Elsevier Ltd. All rights reserved.