Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities
Fitoterapia, cilt.103, ss.289-293, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 103
- Basım Tarihi: 2015
- Doi Numarası: 10.1016/j.fitote.2015.05.003
- Dergi Adı: Fitoterapia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.289-293
- Anahtar Kelimeler: Glycyrrhiza iconica, Fabaceae, Isoflavonoids, Antimicrobial and antioxidant activities, ABSOLUTE-CONFIGURATION, PHENOLIC CONSTITUENTS, CIRCULAR-DICHROISM, GARCINIA-CAMBOGIA, ESSENTIAL OILS, LICORICE, FLAVONOIDS, GLABRA, ROOTS, FRUITS
- Anadolu Üniversitesi Adresli: Evet
Özet
© 2015 Elsevier B.V.Abstract A new prenylated isoflavan, iconisoflavan (1), and a new prenylated isoflav-3-ene, iconisoflaven (2) were isolated from the roots of Glycyrrhiza iconica together with four known ones namely (3S)-licoricidin (3), licorisoflavan A (4), topazolin (5) and glycycoumarin (6). The structures were elucidated on the basis of extensive spectroscopic analysis including 1D and 2D NMR as well as HR-MS. Furthermore, the absolute configurations of compounds 1, 3 and 4 were established by electronic circular dichroism (ECD). All the isolated compounds (1-6) were evaluated for their in vitro antimicrobial activities against five pathogenic bacteria and one yeast (Candida albicans) using an in vitro microdilution method. Compounds 1 and 3-5 displayed significant activity against Salmonella typhimurium ATCC 13311 with MIC values ranging from 2 to 8 μg/mL. Additionally, all compounds were screened for their in vitro free radical scavenging activities using an in vitro microdilution DPPH assay spectrofotometrically. The tested compounds exhibited IC