Inhibition of NF-kappa B-mediated transcription and induction of apoptosis in human breast cancer cells by epoxypseudoisoeugenol-2-methyl butyrate

Ma G., Tabanca N., BAŞER K. H. C., KIRIMER N., Pasco D. S., Khan I. A., ...More

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.63, no.4, pp.673-680, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1007/s00280-008-0784-9
  • Journal Name: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.673-680
  • Keywords: Phenylpropranoid, NF-kappa B, Cyclin D-1, Breast cancer, Cell cycle, Apoptosis, ESTROGEN-RECEPTOR, ESSENTIAL OILS, CYCLIN D1, EXPRESSION, TARGET, GROWTH, PROTEINS, CARCINOMA, THERAPY, SCREEN
  • Anadolu University Affiliated: Yes

Abstract

Purpose Breast cancer is one of the most prevalent woman cancers. Genomic instability, accumulative mutations, and subsequent changes in intracellular signaling cascades play key roles in the development of human breast cancers. Activation of nuclear factor-kappa B(NF-kappa B) has been implicated in oncogenesis of breast cancers and is known to be associated with resistance to anticancer agents and apoptosis. Blocking NF-kappa B signaling may represent a therapeutic strategy in breast cancer therapy. The objective of this study is to investigate the in vitro effects of epoxypseudoisoeugenol-2-methyl butyrate (EPB), a phenylpropranoid isolated from Pimpinella corymbosa, on the activation of NF-kappa B, cell growth, cell cycle progression and apoptosis in MCF-7 (estrogen-dependent) and BT-549 (estrogen-independent) breast cancer cells.