Evaluation of new sulfathiazole derivatives as antiproliferative agents

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YURTTAŞ L., AKALIN ÇİFTÇİ G., TEMEL H. E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.46, no.5, pp.533-539, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.1515/tjb-2020-0238
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.533-539
  • Keywords: cathepsin inhibition, cytotoxicity, matrix metalloproteinase-9 inhibition, sulfathiazole, sulfonamide, MATRIX-METALLOPROTEINASE INHIBITORS, CARBONIC-ANHYDRASE, SULFONAMIDE, ANTICANCER, DISCOVERY, PROTEASES, MOIETIES, ASSAY, DRUG, UREA
  • Anadolu University Affiliated: Yes

Abstract

Objectives: Sulfonamide group is an important scaffold used for generating new building blocks with diverse biological activities. Considering priority of the sulfonamide structure, seven new sulfathiazole derivatives were synthesized and evaluated for their antiproliferative activity, in this study.