Evaluation of new sulfathiazole derivatives as antiproliferative agents

Creative Commons License

YURTTAŞ L., AKALIN ÇİFTÇİ G., TEMEL H. E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.46, sa.5, ss.533-539, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/tjb-2020-0238
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.533-539
  • Anahtar Kelimeler: cathepsin inhibition, cytotoxicity, matrix metalloproteinase-9 inhibition, sulfathiazole, sulfonamide, MATRIX-METALLOPROTEINASE INHIBITORS, CARBONIC-ANHYDRASE, SULFONAMIDE, ANTICANCER, DISCOVERY, PROTEASES, MOIETIES, ASSAY, DRUG, UREA
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objectives: Sulfonamide group is an important scaffold used for generating new building blocks with diverse biological activities. Considering priority of the sulfonamide structure, seven new sulfathiazole derivatives were synthesized and evaluated for their antiproliferative activity, in this study.