GASTROPROTECTIVE EFFECT OF NITRENDIPINE ON STRESS-INDUCED GASTRIC-LESIONS IN RATS

ULAK G., CINGI M., EROL K.

PHARMACOLOGY, vol.43, no.4, pp.220-224, 1991 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 4
  • Publication Date: 1991
  • Doi Number: 10.1159/000138848
  • Journal Name: PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.220-224
  • Keywords: CA2+ CHANNEL BLOCKERS, NITRENDIPINE, STRESS ULCER, INDOMETHACIN, DEXAMETHASONE, PLATELET-ACTIVATING FACTOR, CALCIUM-CHANNEL BLOCKERS, ACID-SECRETION, VERAPAMIL, INDOMETHACIN, LEUKOTRIENES, ETHANOL, ASPIRIN, CELLS
  • Anadolu University Affiliated: No

Abstract

The effects of nitrendipine on stress-induced acute gastric lesions were investigated in rats. Intraperitoneally injected nitrendipine (8, 16, or 32 mg/kg) given 30 min before stress, dose-dependently prevented gastric glandular ulceration. The anti-ulcer effects of nitrendipine were not reversible by indometacin or dexamethasone. These results suggest that calcium is important in gastric pathophysiology and that the proof of gastroprotective effects of calcium channel blockers is of great value in the development of new and improved therapies for treatment and prevention of gastric ulcers in humans.