This study examines a moderated mediation model based on hypothesized relationships between loneliness, travel nostalgia, subjective well-being and prevention regulatory focus. We adopt a two-stage mixed-method approach. We develop and propose an integrative model of loneliness, travel nostalgia and subjective well-being from our qualitative findings. We then test the model on 774 participants from two different samples. Findings indicate that loneliness has a negative effect on individuals’ subjective well-being, and a positive and significant effect between travel nostalgia and individuals’ subjective well-being. Furthermore, this study confirms the significant impact of prevention regulatory focus on the relationship between travel nostalgia and subjective well-being. Theoretical and practical implications are discussed.