Efficient Preparation of Aminoxyacyl Amides, Aminoxy Hybrid Peptides, and alpha-Aminoxy Peptides

Katritzky A. R., Avan I., Tala S. R.

JOURNAL OF ORGANIC CHEMISTRY, cilt.74, sa.22, ss.8690-8694, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 22
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1021/jo901612j
  • Dergi Adı: JOURNAL OF ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
  • Sayfa Sayıları: ss.8690-8694
  • Anadolu Üniversitesi Adresli: Evet

Özet

N-(Pg-alpha-aminoxy acids) 1a-g are converted to N-(Pg-alpha-aminoxyacyl)benzotriazoles 2a-g, Which react under mild conditions with amines, alpha-amino acids/alpha-dipeptides, and alpha-aminoxy acids to give aminoxyacyl amides 3a-g, (3e + 3e'), and (3g + 3g'), aminoxy hybrid peptides 4a-h, (4a + 4a'), 6a-d, 9a-c, (9a + 9a'), and (9b + 9b'), and a-aminoxy peptides 10a,b in good yields without racemization.