Niclosamide Suppresses Proliferation, Induces Apoptosis and Inhibits Wnt/beta-catenin Signaling Pathway in Human Ovarian Cancer Cells

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Gundogdu A. C., TAKE KAPLANOĞLU G., SİVAS H., Varol R., SEYMEN C. M.

GAZI MEDICAL JOURNAL, vol.30, no.2, pp.178-183, 2019 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.12996/gmj.2019.43
  • Journal Name: GAZI MEDICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.178-183
  • Keywords: OVCAR-3, niclosamide, 5-fluorouracil, Wnt/beta-catenin, proliferation, apoptosis, MECHANISMS, ERLOTINIB, PROTEINS, ANALOGS, GROWTH, STAT3
  • Anadolu University Affiliated: Yes

Abstract

Objective: The aim of this study is to investigate in vitro effects of an antihelminthic drug niclosamide on human ovarian carcinoma cell line OVCAR3.