Synthesis of Some Benzothiazole Based Piperazine-Dithiocarbamate Derivatives and Evaluation of Their Anticancer Activities

Turan-Zitouni G., ÖZKAY Y., ÖZDEMİR A., KAPLANCIKLI Z. A., ALTINTOP M. D.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.8, no.9, pp.830-837, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 9
  • Publication Date: 2011
  • Doi Number: 10.2174/157018011797200786
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.830-837
  • Keywords: Anticancer activity, Benzothiazole, Dithiocarbamate, LOX IMVI cell line, Melonoma, Piperazine, ARYL-HYDROCARBON RECEPTOR, ANTITUMOR BENZOTHIAZOLES, 4(3H)-QUINAZOLINONE DERIVATIVES, BIOLOGICAL-PROPERTIES, DRUG DISCOVERY, INHIBITORS, TOXICITY, AGENT, AMIDE
  • Anadolu University Affiliated: Yes

Abstract

Some benzothiazole derivatives bearing piperazine and dithiocarbamate moieties were synthesized in order to investigate their anticancer activity. The structures of the obtained compounds were confirmed by spectral data and elemental analysis. Synthesized compounds were evaluated for their anticancer activity at the National Cancer Institute against a panel of approximately 60 different human tumor cell lines derived from nine neoplastic cancer types. Compound 3f was found to be significantly active against all cancer types in single concentration assay and selected for second step which includes five concentration assays. In the second step, it exhibited very significant activity on melanoma (LOX IMVI) cell line.