Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities

Karakaya A., Çevik U. A., Erçetin T., ÖZKAY Y., KAPLANCIKLI Z. A.

Pharmaceutical Chemistry Journal, cilt.57, sa.9, ss.1439-1443, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 9
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s11094-023-03007-8
  • Dergi Adı: Pharmaceutical Chemistry Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core
  • Sayfa Sayıları: ss.1439-1443
  • Anahtar Kelimeler: acetylcholinesterase, butyrylcholinesterase, imidazole, spectroscopic method, thiazole
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, the synthesis of the planned compounds was carried out in two steps. In the first step, 1-methylimidazole-2-carbaldehyde compound was reacted with thiosemicarbazide and thiosemicarbazone compound was obtained. In the second step, the thiosemicarbazone compound obtained in the first step was reacted with 2-bromoacetophenone derivative compounds and thiazole derivative compounds were obtained. The structures of the synthesized compounds were confirmed by 13C NMR, 1H NMR and HRMS spectral findings, and the melting point was determined for these compounds. The % inhibition values of the compounds on the enzyme acetylcholinesterase (AChE) and butyrylcholinesterase (BuCHe) were investigated.