New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies

ÖZDEMİR A., SEVER B., ALTINTOP M. D.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.16, sa.1, ss.82-92, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1570180815666180326152726
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.82-92
  • Anahtar Kelimeler: Pyrazoline, benzodioxole, CYP51, anticandidal activity, cytotoxicity, docking studies, BIOLOGICAL EVALUATION, CANDIDA-ALBICANS, INVASIVE CANDIDIASIS, DRUG DISCOVERY, ANTIFUNGAL, BEARING, MOIETY, CYTOTOXICITY, INHIBITORS, ANTITUMOR
  • Anadolu Üniversitesi Adresli: Evet

Özet

Background: Azoles are commonly used in the treatment and prevention of fungal infections. They suppress fungal growth by acting on the heme group of lanosterol 14 alpha-demethylase enzyme (CYP51), thus blocking the biosynthesis of ergosterol.