SYNTHESIS AND PHARMACOLOGY OF SOME NEW CARBAMODITHIOIC ACID-ESTERS
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, vol.42-1, no.2, pp.123-126, 1992 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 42-1 Issue: 2
- Publication Date: 1992
- Journal Name: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.123-126
- Keywords: ANTIHISTAMINICS, CARBAMODITHIOIC ACID ESTERS, DITHIOCARBAMATES, PHARMACOLOGY, SYNTHESIS
- Anadolu University Affiliated: No
Abstract
In this study 13 new dithiocarbamates were prepared by reacting 3-methyl-6-chloroacetyl-benzoxazolinone with potassium N,N-disubstituted dithiocarbamate derivatives. The structures of the compounds were confirmed by UV, IR, H-1-NMR, mass spectroscopic methods and elementary analysis. The anticholinergic activity was tested on rabbit ileum. With exception of one compound all derivatives exhibited a stronger antihistaminic activity as compared with their anticholinergic action.