SYNTHESIS AND PHARMACOLOGY OF SOME NEW CARBAMODITHIOIC ACID-ESTERS

SAFAK C., ERDOGAN H., YESILADA A., EROL K., CIMGI I.

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, cilt.42-1, sa.2, ss.123-126, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42-1 Sayı: 2
  • Basım Tarihi: 1992
  • Dergi Adı: ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-126
  • Anahtar Kelimeler: ANTIHISTAMINICS, CARBAMODITHIOIC ACID ESTERS, DITHIOCARBAMATES, PHARMACOLOGY, SYNTHESIS
  • Anadolu Üniversitesi Adresli: Hayır

Özet

In this study 13 new dithiocarbamates were prepared by reacting 3-methyl-6-chloroacetyl-benzoxazolinone with potassium N,N-disubstituted dithiocarbamate derivatives. The structures of the compounds were confirmed by UV, IR, H-1-NMR, mass spectroscopic methods and elementary analysis. The anticholinergic activity was tested on rabbit ileum. With exception of one compound all derivatives exhibited a stronger antihistaminic activity as compared with their anticholinergic action.