JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, vol.45, no.5-8, pp.66-83, 2022 (SCI-Expanded)
Article / Article
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
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Anti-epileptic drugs, epilepsy, liquid chromatography, separation, TANDEM MASS-SPECTROMETRY, FLUORESCENT POLARIZATION IMMUNOASSAY, BIOANALYTICAL METHOD DEVELOPMENT, SOLID-PHASE MICROEXTRACTION, PROCESS-RELATED IMPURITIES, AMPA RECEPTOR ANTAGONIST, PARTIAL-ONSET SEIZURES, RP-HPLC METHOD, ESLICARBAZEPINE ACETATE, HUMAN PLASMA
Anadolu University Affiliated:
Pregabalin, Lacosamide, Rufinamide, Perampanel, Eslicarbazepine acetate, Brivaracetam, Cannabidiol, Stiripentol, Everolimus, Cenobamate, and Fenfluramine are drugs of the third generation of antiepileptic drugs registered by International Coalition of Medicine Regulatory Authorities between 2000 and 2021. There are 213 peer-reviewed papers on antiepileptic drug analysis in the literature over the last three decades (1990-2022) which were reviewed in this article to provide an extensive overview of liquid chromatography techniques used to determine antiepileptic drugs. These details were discussed on the basis of a matrix: additives that are used to prepare a dosage form, sample preparation technique, column, limits of detection and quantification, types of elution in chromatography (isocratic or gradient), and detector. This review article will provide vital information to the scientific community in order to identify the most appropriate approach for antiepileptic drug analysis and determination.