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Acta Pharmaceutica Sciencia, vol.63, no.2, pp.419-430, 2025 (Scopus)
Rosa canina L., belonging to the Rosaceae family, is the most common Rosa species found in Türkiye. Known commonly as rosehip, it is widely used in various traditional medicines. This study investigates the antioxidant activities of ethanol and water extracts of rosehip (Rosa canina L.) fruit samples naturally grown in Sivas. Using DPPH and ABTS assays, we measured the antioxidant capacities of the samples and compared results based on the solvents. Findings show that the ethanol extract exhibited a higher antioxidant capacity, with an IC50 value of 13.28 ± 1.3 μg/mL in the DPPH assay and 24.98 ± 5.3 μg/mL in the ABTS assay, compared to the water extract with IC50 values of 18.099 ± 2.4 μg/mL and 38.47 ± 6.1 μg/mL, respectively. These results suggest that rosehip fruits could serve as effective sources for antioxidant-rich pharmaceutical products, with ethanol extracts demonstrating a stronger antioxidant effect than water extracts.