A facile protocol for the preparation of 5-alkylidene and 5-imino substituted hydantoins from N,N '-disubstituted parabanic acids

ÜNGÖREN Ş. H., KANİ İ., Gunay A.

TETRAHEDRON LETTERS, vol.53, no.35, pp.4758-4762, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 35
  • Publication Date: 2012
  • Doi Number: 10.1016/j.tetlet.2012.06.129
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
  • Page Numbers: pp.4758-4762
  • Keywords: Wittig reactions, Hydantoins, Imidazolidine, Parabanic acid derivatives, Iminophosphoranes, DERIVATIVES, NITROGEN, UREAS
  • Anadolu University Affiliated: Yes


A convenient procedure for the preparation of various substituted (thio)hydantoins is described. The method is based on Wittig and aza-Wittig reactions of parabanic acids with phosphonium ylides. The reactions occurred both regio- and stereo-selectively. (c) 2012 Elsevier Ltd. All rights reserved.