A facile protocol for the preparation of 5-alkylidene and 5-imino substituted hydantoins from N,N '-disubstituted parabanic acids
TETRAHEDRON LETTERS, vol.53, no.35, pp.4758-4762, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 53 Issue: 35
- Publication Date: 2012
- Doi Number: 10.1016/j.tetlet.2012.06.129
- Journal Name: TETRAHEDRON LETTERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
- Page Numbers: pp.4758-4762
- Keywords: Wittig reactions, Hydantoins, Imidazolidine, Parabanic acid derivatives, Iminophosphoranes, DERIVATIVES, NITROGEN, UREAS
- Anadolu University Affiliated: Yes
Abstract
A convenient procedure for the preparation of various substituted (thio)hydantoins is described. The method is based on Wittig and aza-Wittig reactions of parabanic acids with phosphonium ylides. The reactions occurred both regio- and stereo-selectively. (c) 2012 Elsevier Ltd. All rights reserved.