Phenolic composition and biological activities of Salvia halophila and Salvia virgata from Turkey

AKKOL E., GÖGER F., Kosar M., BAŞER K. H. C.

FOOD CHEMISTRY, vol.108, no.3, pp.942-949, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.foodchem.2007.11.071
  • Journal Name: FOOD CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.942-949
  • Keywords: Salvia halophila, Salvia virgata, lamiaceae, anti-inflammatory activity, antinociceptive activity, carrageenan-induced edema, 12-O-tetradecanoyl-13-acetate induced edema, DRUGS, INHIBITION, EDEMA, MICE
  • Anadolu University Affiliated: Yes


The aerial parts of Salvia halophila and Salvia virgata were subjected to Soxhlet extraction with different solvents such as n-hexane, ethyl acetate, methanol, and aqueous methanol (50%). Plants were also extracted with water under reflux. The effects of the extracts were studied in p-benzoquinone-induced abdominal constriction test for the assessment of antinociceptive activity and carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced ear edema models in mice for the anti-inflammatory activity. The extracts were analysed using a HPLC-PDA method. Results showed that methanol extract of S. virgata significantly inhibited carrageenan-induced paw edema and p-benzoquinone-induced abdominal constriction at 100mg/kg dose, while it showed no effect in the TPA-induced car edema. On the other hand, the other extracts did not show any inhibitory antinociceptive and anti-inflammatory activities in these in vivo models. Rosmarinic acid was found as main constituent in the extracts, while caffeic acid and luteolin derivatives were also detected. (c) 2007 Elsevier Ltd. All rights reserved.