Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium

Tosun F., Kizilay C. A., Erol K., KILIÇ F. S., KÜRKÇÜOĞLU M., BAŞER K. H. C.

FOOD CHEMISTRY, vol.107, no.3, pp.990-993, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.foodchem.2007.08.085
  • Journal Name: FOOD CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.990-993
  • Keywords: Heracleum crenatifolium, furanocoumarin, essential oil, anticonvulsant, MES, COUMARINS, ROOTS, CONSTITUENTS, DERIVATIVES, PERSICUM, RAPULA
  • Anadolu University Affiliated: Yes

Abstract

The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice. Bergapten showed significant anticonvulsant activity. The furanocoumarins isolated from the fruits of the plant were identified using thin-layer chromatography, melting points and spectroscopic methods (IR, MS, H-1 NMR) as isobergapten (1), pimpinellin (2), bergapten (3), isopimpinellin (4), sphondin (5) and byak-angelicol (6). The essential oil content of the fruits were found as 5.5%. Twenty-two compounds representing 99.3% of the essential oil obtained from the fruits of H. crenatifolium were determined and the major components were identified as octanol and octyl acetate (3.1% and 88.4% respectively) by GC and GC-MS. (c) 2007 Elsevier Ltd. All rights reserved.